Endocrine Abstracts

Context: Parathyroid carcinoma is a very rare malignancy. It arises as a separate structure rather than from a pre-existing parathyroid adenoma. It may be difficult to differentiate it from parathyroid adenoma based on histology. When evaluating primary hyperparathyroidism clinical correlation should be taken into account. Clinical features of parathyroid carcinoma may include male gender, palpable neck nodule and higher parathyroid hormone and serum calcium levels associated ...

Background: Growing evidence suggests a link between sugar-sweetened beverages (SSBs) and metabolic disorders. We investigated the effect of SSBs that are commonly consumed by adolescents on glucose metabolism and fatty liver.Methods: We treated 7-week old male C57BL/6 mice with water (control) or either of SSBs: carbonated soda (Coca-Cola®), sweetened milk coffee (Maxwell®), or chocolate-added cocoa (Choco-Latte&#174...

Adrenal Lymphoma is extremely rare with fewer than 200 cases reported. The most common subtype is the diffuse large B cell lymphoma. Malignant lymphoma arising in the endocrine glands represents only 3% of extranodal malignant lymphomas and is usually confined to the thyroid gland. NK/T-cell lymphoma presents primarily in the nasopharynx and sinuses. Although involvement of the adrenal glands can be seen in disseminated disease, primary presentation with adrenal masses and adr...

Introduction: Falsely high FT4 and FT3 with concurrent falsely low TSH have been reported in patients taking biotin and in a few case reports of patients with IgG anti-streptavidin antibody. However, other isotypes and effects on other immunoassays have not been reported.Case: A 77 year female presented with worsening fatigue with a background of hyperthyroidism on carbimazole. Clinically she appeared hypothyroid. Her results on Roche Cobas platform were...

About 19 year-old, female, presented with sweating in both arms for many years. The sweating has progressively got worse over the last several years. Occasionally, her feet and lower back can also be affected. They do not tend to occur particularly at night and have no association with alcohol, meals or fasting. Her periods are regular. She does not have any associated symptoms such as headache and visual disturbance.She has no significant family history...

Background: Severe obesity, BMI ≥40 kg/m2, confers a greater risk for graft loss and mortality among renal transplant patients. Transplantation provides a better survival and quality of life in overweight dialysis patients. Higher BMI is associated with progressively increased risk of CKD stages 4–5, hazard ratio of 3.10 (CI 2.95–3.25) for BMI ≥35 kg/m2. A recent meta-analysis found pre-transplant BMI <30 kg/m2 is asso...

Introduction: Malignant struma ovarii is a rare disease, for which risk factors and prognostic features are not well-defined. We present a patient with concomitant Graves’ disease and metastatic follicular thyroid cancer arising from struma ovarii, and discuss the possible mechanism of this association.Clinical case: A 43 year old woman undergoing follow-up for Graves’ disease (GD) presented with an enlarging left lower abdominal mass. She ha...

Introduction: Adrenal insufficiency (AI) is a potential life-threatening emergency with patients presenting with hypovolaemic shock. Although glucocorticoid-induced AI is well known, there are only a few reports of other drug-induced aetiologies.Case Report: A 50-year-old HIV-positive Caucasian female on ritonavir, darunavir, abacavir and lamivudine presented generally unwell with dizziness on standing, fatigue and weakness. Two days prior to admission, ...

Ghrelin is a circulating growth hormone-releasing and appetite-inducing brain–gut peptide. It needs to be acylated on its serine-3 with octanoate for its endocrine actions. The acyl-transferase that catalyses ghrelin octanoylation has been recently identified and named GOAT (ghrelin O-acyltransferase), which is coded by the MBOAT4 gene. This study aimed to investigate GOAT expression in human. The distribution of GOAT mRNA expression was studied in various human ti...

Aim: Previous studies demonstrated lower serum zinc among prediabetics and diabetics, compared to normoglycaemics. There is no current epidemiological data available in regional Australia examining the association between serum zinc and glycaemic status. This study was conducted to determine the relationship between serum zinc, glycaemic status and Homeostasis Model Assessment (HOMA-2) parameters in a regional Australian hospital population.Methods: A re...